Assay Detail
Functional
CHEMBL655592
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Antiviral activity was measured on HIV-1 in wild-type CEM/O cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.86 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL376065 | — | — | 1 | 7.06 |
| CHEMBL31131 | — | — | 1 | 7.05 |
| CHEMBL33528 | — | — | 1 | 6.77 |
| CHEMBL223807 | — | — | 1 | 6.75 |
| CHEMBL991 | STAVUDINE | 4.0 | 2 | 6.75 |
| CHEMBL2115337 | — | — | 1 | 6.75 |
| CHEMBL375767 | — | — | 1 | 6.55 |
| CHEMBL374483 | — | — | 1 | 6.54 |
| CHEMBL266136 | — | — | 1 | 6.38 |
| CHEMBL31187 | — | — | 1 | - |
| CHEMBL280802 | SALICYL ALCOHOL | -1.0 | 1 | - |
| CHEMBL33063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL376065 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL31131 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL33528 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL223807 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL991 | STAVUDINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL991 | STAVUDINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2115337 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL375767 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL374483 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL266136 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL31187 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL280802 | SALICYL ALCOHOL | EC50 | > | 250000.0 | nM | - |
| CHEMBL33063 | — | EC50 | > | 250000.0 | nM | - |