Assay Detail
Functional
CHEMBL655645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of CCRF-CEM human leukemia cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.64 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.84 |
| CHEMBL430872 | — | — | 1 | 7.54 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | — | 1 | 7.33 |
| CHEMBL106628 | — | — | 1 | 6.85 |
| CHEMBL323565 | — | — | 1 | 6.54 |
| CHEMBL1237205 | — | — | 1 | 5.93 |
| CHEMBL2092925 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL430872 | — | EC50 | = | 29.2 | nM | 7.54 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL106628 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL323565 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1237205 | — | EC50 | = | 1175.0 | nM | 5.93 |
| CHEMBL2092925 | — | EC50 | = | 34000.0 | nM | 4.47 |