Assay Detail
Functional
CHEMBL655786
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Tested for cell growth inhibition against CCRF-CEM a human lymphoblastic leukemia line of T-cell origin.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.12 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84163 | — | — | 1 | 8.54 |
| CHEMBL82261 | — | — | 1 | 8.10 |
| CHEMBL85436 | — | — | 1 | 8.05 |
| CHEMBL82390 | — | — | 1 | 8.00 |
| CHEMBL309415 | — | — | 1 | 8.00 |
| CHEMBL315076 | — | — | 1 | 7.54 |
| CHEMBL85871 | — | — | 1 | 7.50 |
| CHEMBL84904 | — | — | 1 | 7.35 |
| CHEMBL84935 | — | — | 1 | 7.32 |
| CHEMBL315627 | — | — | 1 | 7.21 |
| CHEMBL84605 | — | — | 1 | 6.54 |
| CHEMBL84728 | — | — | 1 | 6.18 |
| CHEMBL85848 | — | — | 1 | 5.86 |
| CHEMBL82181 | — | — | 1 | 5.75 |
| CHEMBL84045 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84163 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL82261 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL85436 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL82390 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL309415 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL315076 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL85871 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL84904 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL84935 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL315627 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL84605 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL84728 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL85848 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL82181 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL84045 | — | IC50 | = | 12000.0 | nM | 4.92 |