Assay Detail
Binding
CHEMBL655896
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Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.64 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.44 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 6.01 |
| CHEMBL302179 | — | — | 1 | 5.86 |
| CHEMBL422977 | — | — | 1 | 5.43 |
| CHEMBL132377 | — | — | 1 | 5.22 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 5.21 |
| CHEMBL134382 | — | — | 1 | 5.06 |
| CHEMBL134488 | — | — | 1 | 4.94 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 4.93 |
| CHEMBL132133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL95 | TACRINE | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL27673 | METHOCTRAMINE | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL302179 | — | IC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL422977 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL132377 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL134382 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL134488 | — | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL132133 | — | IC50 | = | 645654.23 | nM | - |