Assay Detail
Binding
CHEMBL655960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50% inhibition of human C1r serine protease after 60 mins using Cbz-Gly-Arg-S-Bzl as substrate
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.30 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274319 | — | — | 1 | 6.10 |
| CHEMBL10252 | — | — | 1 | 6.05 |
| CHEMBL10432 | — | — | 1 | 6.05 |
| CHEMBL10610 | — | — | 1 | 6.05 |
| CHEMBL10132 | — | — | 1 | 6.05 |
| CHEMBL10248 | — | — | 1 | 5.82 |
| CHEMBL274816 | — | — | 1 | 5.70 |
| CHEMBL10435 | — | — | 1 | 5.55 |
| CHEMBL10312 | — | — | 1 | 5.40 |
| CHEMBL10527 | — | — | 1 | 5.38 |
| CHEMBL10065 | — | — | 1 | 5.11 |
| CHEMBL10050 | — | — | 1 | 5.10 |
| CHEMBL276438 | — | — | 1 | 4.83 |
| CHEMBL274211 | — | — | 1 | 4.82 |
| CHEMBL10768 | — | — | 1 | 4.78 |
| CHEMBL10770 | — | — | 1 | 4.78 |
| CHEMBL10396 | — | — | 1 | 4.42 |
| CHEMBL10117 | — | — | 1 | 4.33 |
| CHEMBL10378 | — | — | 1 | 4.30 |
| CHEMBL10554 | — | — | 1 | - |
| CHEMBL10716 | — | — | 1 | - |
| CHEMBL10254 | — | — | 1 | - |
| CHEMBL10276 | — | — | 1 | - |
| CHEMBL10757 | — | — | 1 | - |
| CHEMBL10246 | — | — | 1 | - |
| CHEMBL274137 | — | — | 1 | - |
| CHEMBL10569 | — | — | 1 | - |
| CHEMBL276464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274319 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL10252 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL10432 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL10610 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL10132 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL10248 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL274816 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL10435 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL10312 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL10527 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL10065 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL10050 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL276438 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL274211 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL10768 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL10770 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL10396 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL10117 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL10378 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL10554 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10716 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10254 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10276 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10757 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10246 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL274137 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL10569 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL276464 | — | IC50 | > | 62500.0 | nM | - |