Assay Detail
Binding
CHEMBL655965
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Inhibition of C1r serine protease
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.30 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158926 | — | — | 1 | 6.16 |
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 6.00 |
| CHEMBL157862 | — | — | 1 | 5.77 |
| CHEMBL158577 | — | — | 1 | 5.52 |
| CHEMBL161460 | — | — | 1 | 5.52 |
| CHEMBL352443 | — | — | 1 | 5.38 |
| CHEMBL157987 | — | — | 1 | 5.30 |
| CHEMBL159104 | — | — | 1 | 5.22 |
| CHEMBL162473 | — | — | 1 | 5.12 |
| CHEMBL158541 | — | — | 1 | 5.02 |
| CHEMBL158925 | — | — | 1 | 5.00 |
| CHEMBL161656 | — | — | 1 | 4.92 |
| CHEMBL158462 | — | — | 1 | 4.76 |
| CHEMBL161254 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158926 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL157862 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL158577 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL161460 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL352443 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL157987 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL159104 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL162473 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL158541 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL158925 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL161656 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL158462 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL161254 | — | IC50 | = | 36300.0 | nM | 4.44 |