Assay Detail
Binding
CHEMBL655967
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Inhibitory activity against C1r serine protease
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.49 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 4.92 |
| CHEMBL158577 | — | — | 1 | 4.56 |
| CHEMBL159104 | — | — | 1 | 4.40 |
| CHEMBL158541 | — | — | 1 | 4.34 |
| CHEMBL161460 | — | — | 1 | 4.24 |
| CHEMBL162473 | — | — | 1 | - |
| CHEMBL158925 | — | — | 1 | - |
| CHEMBL161254 | — | — | 1 | - |
| CHEMBL161275 | — | — | 1 | - |
| CHEMBL352443 | — | — | 1 | - |
| CHEMBL345362 | — | — | 1 | - |
| CHEMBL346547 | — | — | 1 | - |
| CHEMBL347904 | — | — | 1 | - |
| CHEMBL161656 | — | — | 1 | - |
| CHEMBL157987 | — | — | 1 | - |
| CHEMBL349853 | — | — | 1 | - |
| CHEMBL349818 | — | — | 1 | - |
| CHEMBL349763 | — | — | 1 | - |
| CHEMBL157862 | — | — | 1 | - |
| CHEMBL158926 | — | — | 1 | - |
| CHEMBL158462 | — | — | 1 | - |
| CHEMBL158801 | — | — | 1 | - |
| CHEMBL159105 | — | — | 1 | - |
| CHEMBL157808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL158577 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL159104 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL158541 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL161460 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL162473 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL158925 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL161254 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL161275 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL352443 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL345362 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL346547 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL347904 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL161656 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL157987 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL349853 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL349818 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL349763 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL157862 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL158926 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL158462 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL158801 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL159105 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL157808 | — | IC50 | > | 62500.0 | nM | - |