Assay Detail
Binding
CHEMBL656039
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Inhibitory activity against serine Beta-lactamase TEM derived from Staphylococcus aureus
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.41 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294203 | — | — | 1 | 8.40 |
| CHEMBL292093 | — | — | 1 | 7.81 |
| CHEMBL294608 | — | — | 1 | 7.40 |
| CHEMBL303053 | — | — | 1 | 7.22 |
| CHEMBL305361 | — | — | 1 | 6.98 |
| CHEMBL61762 | — | — | 1 | 6.75 |
| CHEMBL64793 | — | — | 1 | 6.71 |
| CHEMBL292506 | — | — | 1 | 6.63 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 6.53 |
| CHEMBL304709 | — | — | 1 | 6.51 |
| CHEMBL60491 | — | — | 1 | 5.75 |
| CHEMBL61760 | — | — | 1 | 5.74 |
| CHEMBL59053 | — | — | 1 | 5.62 |
| CHEMBL64056 | — | — | 1 | 5.57 |
| CHEMBL60220 | — | — | 1 | 4.66 |
| CHEMBL292147 | — | — | 1 | 4.35 |
| CHEMBL59227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294203 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL292093 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL294608 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL303053 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL305361 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL61762 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL64793 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL292506 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL304709 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL60491 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL61760 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL59053 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL64056 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL60220 | — | IC50 | = | 21670.0 | nM | 4.66 |
| CHEMBL292147 | — | IC50 | = | 44510.0 | nM | 4.35 |
| CHEMBL59227 | — | IC50 | = | 120500.0 | nM | - |