Assay Detail
Binding
CHEMBL656040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for inhibition against Beta-lactamase TEM derived from Staphylococcus aureus
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.14 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268919 | — | — | 1 | 7.52 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 6.54 |
| CHEMBL169515 | — | — | 1 | 6.03 |
| CHEMBL169016 | — | — | 1 | 5.95 |
| CHEMBL355246 | — | — | 1 | 4.50 |
| CHEMBL268632 | — | — | 1 | 4.46 |
| CHEMBL355648 | — | — | 1 | 4.25 |
| CHEMBL435467 | — | — | 1 | 4.13 |
| CHEMBL166730 | — | — | 1 | 4.04 |
| CHEMBL353004 | — | — | 1 | 4.00 |
| CHEMBL355571 | — | — | 1 | - |
| CHEMBL171001 | — | — | 1 | - |
| CHEMBL166677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268919 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL169515 | — | IC50 | = | 932.0 | nM | 6.03 |
| CHEMBL169016 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL355246 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL268632 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL355648 | — | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL435467 | — | IC50 | = | 74100.0 | nM | 4.13 |
| CHEMBL166730 | — | IC50 | = | 91100.0 | nM | 4.04 |
| CHEMBL353004 | — | IC50 | = | 99200.0 | nM | 4.00 |
| CHEMBL355571 | — | IC50 | = | 498000.0 | nM | - |
| CHEMBL171001 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL166677 | — | IC50 | = | 277000.0 | nM | - |