Assay Detail
Functional
CHEMBL656045
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Tested for cytotoxicity in human T-cell lymphoblastic leukemia cell line (CEM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of beta-L-FD4C as potent anti-HBV agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.59 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 4.89 |
| CHEMBL346321 | — | — | 1 | 4.89 |
| CHEMBL158294 | — | — | 1 | 4.28 |
| CHEMBL348374 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL346321 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL158294 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL348374 | — | IC50 | = | 52000.0 | nM | 4.28 |