Assay Detail
Functional
CHEMBL656060
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Compound was tested for the inhibition of human CCRF-CEM leukemia cell growth
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.29 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171057 | — | — | 1 | 6.05 |
| CHEMBL352620 | — | — | 1 | 5.75 |
| CHEMBL56662 | — | — | 1 | 5.66 |
| CHEMBL169726 | — | — | 1 | 5.48 |
| CHEMBL301256 | — | — | 1 | 5.41 |
| CHEMBL168524 | — | — | 1 | 5.40 |
| CHEMBL171314 | — | — | 1 | 5.29 |
| CHEMBL169727 | — | — | 1 | 5.10 |
| CHEMBL353700 | — | — | 1 | 4.96 |
| CHEMBL169921 | — | — | 1 | 4.66 |
| CHEMBL169411 | — | — | 1 | 4.40 |
| CHEMBL353813 | — | — | 1 | - |
| CHEMBL172176 | — | — | 1 | - |
| CHEMBL353191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171057 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL352620 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL56662 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL169726 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL301256 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL168524 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL171314 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL169727 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL353700 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL169921 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL169411 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL353813 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL172176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL353191 | — | IC50 | > | 10000.0 | nM | - |