Assay Detail
Functional
CHEMBL656065
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Concentration required for the 50% inhibition of growth of CCRF-CEM human leukemia cells in culture
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.36 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 7.30 |
| CHEMBL603288 | — | — | 1 | 6.18 |
| CHEMBL603285 | — | — | 1 | 5.75 |
| CHEMBL606121 | — | — | 1 | 5.51 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.30 |
| CHEMBL603284 | — | — | 1 | 4.66 |
| CHEMBL1130 | DOXIFLURIDINE | 3.0 | 1 | 4.66 |
| CHEMBL603289 | — | — | 1 | 4.57 |
| CHEMBL604072 | — | — | 1 | 4.31 |
| CHEMBL603181 | — | — | 1 | - |
| CHEMBL603287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL603288 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL603285 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL606121 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL603284 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1130 | DOXIFLURIDINE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL603289 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL604072 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL603181 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL603287 | — | IC50 | = | 140000.0 | nM | - |