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Assay Detail

CHEMBL656068

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Functional
Cytotoxic activity against human acute lymphoblastic leukemia (CCRF-CEM) cell line
ChEMBL ↗
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Expert

Target

CCRF-CEM (CHEMBL382) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.
Easmon J, Pürstinger G, Heinisch G, Roth T, Fiebig HH, Holzer W, Jäger W, Jenny M, Hofmann J.
J Med Chem (2001) 44 : 2164 -2171
PubMed 11405653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.16 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL303030 N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 8.30
CHEMBL68899 — — 1 8.30
CHEMBL71931 N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 8.22
CHEMBL307750 N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 8.00
CHEMBL69491 — — 1 7.96
CHEMBL68043 — — 1 7.96
CHEMBL307351 — — 1 7.75
CHEMBL66382 — — 1 7.70
CHEMBL66328 Fe (II) complex — 1 7.16
CHEMBL69107 Fe (II) complex — 1 7.16
CHEMBL67816 N-[(1E)-1-(6-methylpyridazin-3-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 6.89
CHEMBL68968 Copper(II) Complex — 1 6.52
CHEMBL68910 — — 1 6.48
CHEMBL308445 — — 1 6.22
CHEMBL68993 — — 1 6.11
CHEMBL69031 Fe (II) complex — 1 6.09
CHEMBL305532 Fe (II) complex — 1 6.09
CHEMBL69122 Fe (II) complex — 1 5.94
CHEMBL66349 N-[(1E)-1-pyrazin-2-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 -
CHEMBL69182 N-[(1E)-1-pyrimidin-4-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL303030 N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 5.0 nM 8.30
CHEMBL68899 — IC50 = 5.0 nM 8.30
CHEMBL71931 N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 6.0 nM 8.22
CHEMBL307750 N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 10.0 nM 8.00
CHEMBL69491 — IC50 = 11.0 nM 7.96
CHEMBL68043 — IC50 = 11.0 nM 7.96
CHEMBL307351 — IC50 = 18.0 nM 7.75
CHEMBL66382 — IC50 = 20.0 nM 7.70
CHEMBL66328 Fe (II) complex IC50 = 70.0 nM 7.16
CHEMBL69107 Fe (II) complex IC50 = 70.0 nM 7.16
CHEMBL67816 N-[(1E)-1-(6-methylpyridazin-3-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 130.0 nM 6.89
CHEMBL68968 Copper(II) Complex IC50 = 300.0 nM 6.52
CHEMBL68910 — IC50 = 330.0 nM 6.48
CHEMBL308445 — IC50 = 600.0 nM 6.22
CHEMBL68993 — IC50 = 770.0 nM 6.11
CHEMBL69031 Fe (II) complex IC50 = 810.0 nM 6.09
CHEMBL305532 Fe (II) complex IC50 = 820.0 nM 6.09
CHEMBL69122 Fe (II) complex IC50 = 1160.0 nM 5.94
CHEMBL66349 N-[(1E)-1-pyrazin-2-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 < 10.0 nM -
CHEMBL69182 N-[(1E)-1-pyrimidin-4-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 < 10.0 nM -