Assay Detail
Functional
CHEMBL656071
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Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of N-(2-pyridylsulfenyl)urea derivatives. A new class of potential antineoplastic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.59 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL77093 | — | — | 1 | 6.16 |
| CHEMBL77950 | — | — | 1 | 5.82 |
| CHEMBL75064 | — | — | 1 | 5.46 |
| CHEMBL430989 | — | — | 1 | 5.37 |
| CHEMBL309813 | — | — | 1 | 4.82 |
| CHEMBL7643 | SULOFENUR | 2.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL77093 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL77950 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL75064 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL430989 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL309813 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL7643 | SULOFENUR | IC50 | = | 32000.0 | nM | 4.50 |