Assay Detail
Functional
CHEMBL656072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human leukemic CCRF-CEM cells.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.83 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510650 | ECHINOMYCIN | — | 1 | 6.30 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 5.80 |
| CHEMBL409466 | CHROMOMYCIN | — | 1 | 5.46 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 5.44 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.28 |
| CHEMBL345599 | — | — | 1 | 4.46 |
| CHEMBL153957 | — | — | 1 | 4.33 |
| CHEMBL348593 | — | — | 1 | 4.30 |
| CHEMBL504459 | NOGALAMYCIN | 2.0 | 1 | 4.23 |
| CHEMBL156735 | — | — | 1 | 4.20 |
| CHEMBL358174 | — | — | 1 | 4.12 |
| CHEMBL345716 | — | — | 1 | 4.06 |
| CHEMBL157068 | — | — | 1 | - |
| CHEMBL154288 | — | — | 1 | - |
| CHEMBL345653 | — | — | 1 | - |
| CHEMBL153954 | — | — | 1 | - |
| CHEMBL154010 | — | — | 1 | - |
| CHEMBL417526 | — | — | 1 | - |
| CHEMBL349579 | — | — | 1 | - |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | - |
| CHEMBL155250 | — | — | 1 | - |
| CHEMBL348048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510650 | ECHINOMYCIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL409466 | CHROMOMYCIN | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL345599 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL153957 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL348593 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL504459 | NOGALAMYCIN | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL156735 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL358174 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL345716 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL157068 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL154288 | — | IC50 | = | 710000.0 | nM | - |
| CHEMBL345653 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL153954 | — | IC50 | = | 810000.0 | nM | - |
| CHEMBL154010 | — | IC50 | = | 3800000.0 | nM | - |
| CHEMBL417526 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL349579 | — | IC50 | = | 590000.0 | nM | - |
| CHEMBL43 | AMSACRINE | IC50 | = | 130000.0 | nM | - |
| CHEMBL155250 | — | IC50 | = | 710000.0 | nM | - |
| CHEMBL348048 | — | IC50 | = | 290000.0 | nM | - |