Assay Detail
Functional
CHEMBL656076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human CCRF-CEM T-lymphoblastic leukemia cells was determined
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.65 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40724 | — | — | 2 | 5.70 |
| CHEMBL853 | ZALCITABINE | 4.0 | 2 | 4.55 |
| CHEMBL277900 | — | — | 1 | - |
| CHEMBL167971 | — | — | 1 | - |
| CHEMBL2115012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40724 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL40724 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL277900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL167971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2115012 | — | IC50 | > | 100000.0 | nM | - |