Assay Detail
Functional
CHEMBL656078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human leukemia CCRF-CEM tumor cell lines
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel cryptophycin antitumor agents: synthesis and cytotoxicity of fragment "B" analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.17 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313330 | — | — | 1 | 10.66 |
| CHEMBL84700 | — | — | 1 | 10.27 |
| CHEMBL314522 | — | — | 1 | 9.74 |
| CHEMBL85272 | — | — | 1 | 9.28 |
| CHEMBL89619 | — | — | 1 | 9.24 |
| CHEMBL86941 | — | — | 1 | 8.39 |
| CHEMBL432373 | — | — | 1 | 8.06 |
| CHEMBL407385 | — | — | 1 | 8.00 |
| CHEMBL86762 | — | — | 1 | 7.86 |
| CHEMBL84845 | — | — | 1 | 7.82 |
| CHEMBL86849 | — | — | 1 | 7.51 |
| CHEMBL86696 | — | — | 1 | 7.46 |
| CHEMBL86423 | — | — | 1 | 7.32 |
| CHEMBL409074 | — | — | 1 | 6.94 |
| CHEMBL89788 | — | — | 1 | 6.60 |
| CHEMBL313947 | — | — | 1 | 6.57 |
| CHEMBL433337 | — | — | 1 | 6.56 |
| CHEMBL314688 | — | — | 1 | 6.49 |
| CHEMBL87165 | — | — | 1 | 6.38 |
| CHEMBL262960 | — | — | 1 | 6.30 |
| CHEMBL85841 | — | — | 1 | 6.22 |
| CHEMBL88030 | — | — | 1 | 6.22 |
| CHEMBL86873 | — | — | 1 | 6.13 |
| CHEMBL86812 | — | — | 1 | 6.07 |
| CHEMBL328454 | — | — | 1 | 6.06 |
| CHEMBL87490 | — | — | 1 | 6.01 |
| CHEMBL315267 | — | — | 1 | 6.00 |
| CHEMBL1790732 | — | — | 1 | 5.97 |
| CHEMBL313031 | — | — | 1 | 5.89 |
| CHEMBL406149 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313330 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL84700 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL314522 | — | IC50 | = | 0.183 | nM | 9.74 |
| CHEMBL85272 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL89619 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL86941 | — | IC50 | = | 4.108 | nM | 8.39 |
| CHEMBL432373 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL407385 | — | IC50 | = | 10.11 | nM | 8.00 |
| CHEMBL86762 | — | IC50 | = | 13.85 | nM | 7.86 |
| CHEMBL84845 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL86849 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL86696 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL86423 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL409074 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL89788 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL313947 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL433337 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL314688 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL87165 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL262960 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL85841 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL88030 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL86873 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL86812 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL328454 | — | IC50 | = | 866.0 | nM | 6.06 |
| CHEMBL87490 | — | IC50 | = | 975.0 | nM | 6.01 |
| CHEMBL315267 | — | IC50 | = | 997.0 | nM | 6.00 |
| CHEMBL1790732 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL313031 | — | IC50 | = | 1301.0 | nM | 5.89 |
| CHEMBL406149 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL89807 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL313117 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL315826 | — | IC50 | > | 1620.0 | nM | - |
| CHEMBL89775 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL86606 | — | IC50 | > | 1940.0 | nM | - |
| CHEMBL89120 | — | IC50 | > | 1840.0 | nM | - |
| CHEMBL85338 | — | IC50 | > | 1850.0 | nM | - |
| CHEMBL90220 | — | IC50 | > | 1800.0 | nM | - |
| CHEMBL314892 | — | IC50 | > | 1680.0 | nM | - |
| CHEMBL86541 | — | IC50 | > | 1860.0 | nM | - |
| CHEMBL316269 | — | IC50 | > | 1570.0 | nM | - |
| CHEMBL275010 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL329832 | — | IC50 | > | 1690.0 | nM | - |
| CHEMBL87666 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL86769 | — | IC50 | > | 1570.0 | nM | - |