Assay Detail
Functional
CHEMBL656080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity of compounds were determined on Inhibition of human leukemia cell line(CCRF-CEM).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 8.70 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 8.26 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.05 |
| CHEMBL307679 | — | — | 1 | 7.00 |
| CHEMBL1791078 | — | — | 1 | 6.50 |
| CHEMBL96148 | — | — | 1 | 6.50 |
| CHEMBL607603 | — | — | 1 | - |
| CHEMBL1791434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL803 | CYTARABINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL307679 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1791078 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL96148 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL607603 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL1791434 | — | IC50 | = | 195000.0 | nM | - |