Assay Detail
Functional
CHEMBL656108
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Antiviral activity in CEM-SS cell line infected with HIV-1 and Concentration required to inhibit the replication of HIV-1 by 50% was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.53 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL291344 | — | — | 1 | 7.82 |
| CHEMBL418469 | — | — | 1 | 7.66 |
| CHEMBL126557 | — | — | 1 | 7.64 |
| CHEMBL262678 | — | — | 1 | 7.34 |
| CHEMBL129229 | — | — | 1 | 7.11 |
| CHEMBL340610 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL291344 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL418469 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL126557 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL262678 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL129229 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL340610 | — | EC50 | = | 125.0 | nM | 6.90 |