Assay Detail

CHEMBL656109

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HIV-1 in CEM-SS cells using XXT assay

ChEMBL ↗

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Target

CEM-SS (CHEMBL614548) ↗

Open DB target context

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Primary target CEM-SS

CHEMBL614548

Anchored from Assay target.

Protein identity CEM-SS

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CEM-SS
Confidence	1 — Organism
Curated By	Intermediate

Target

CEM-SS (CHEMBL614548) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.

McDonnell NB, De Guzman RN, Rice WG, Turpin JA, Summers MF.
J Med Chem (1997) 40 : 1969 -1976
PubMed 9207937 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	4.32	4.38

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL602	CYSTEAMINE	4.0	1	4.38
CHEMBL61350	CYSTAMINE	—	1	4.25

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL602	CYSTEAMINE	EC50	=	41600.0	nM	4.38
CHEMBL61350	CYSTAMINE	EC50	=	56200.0	nM	4.25