Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL656175

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against progesterone induced PRE-luciferase activity in CV-cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones.
Zhang P, Terefenko EA, Wrobel J, Zhang Z, Zhu Y, Cohen J, Marschke KB, Mais D.
Bioorg Med Chem Lett (2001) 11 : 2747 -2750
PubMed 11591515 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.70 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276308 MIFEPRISTONE 4.0 1 9.52
CHEMBL93027 1 7.38
CHEMBL328332 1 6.97
CHEMBL327444 1 6.87
CHEMBL327409 1 6.59
CHEMBL94053 1 6.58
CHEMBL315445 1 6.49
CHEMBL329631 1 6.38
CHEMBL92026 1 6.38
CHEMBL330271 1 5.86
CHEMBL92354 1 5.82
CHEMBL94162 1 5.51
CHEMBL313850 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276308 MIFEPRISTONE IC50 = 0.3 nM 9.52
CHEMBL93027 IC50 = 42.0 nM 7.38
CHEMBL328332 IC50 = 106.0 nM 6.97
CHEMBL327444 IC50 = 135.7 nM 6.87
CHEMBL327409 IC50 = 257.3 nM 6.59
CHEMBL94053 IC50 = 265.0 nM 6.58
CHEMBL315445 IC50 = 326.0 nM 6.49
CHEMBL329631 IC50 = 412.0 nM 6.38
CHEMBL92026 IC50 = 412.0 nM 6.38
CHEMBL330271 IC50 = 1370.0 nM 5.86
CHEMBL92354 IC50 = 1529.0 nM 5.82
CHEMBL94162 IC50 = 3061.0 nM 5.51
CHEMBL313850 IC50 > 10000.0 nM -