Assay Detail
Binding
CHEMBL656244
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In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
L-708,474: The C5-cyclohexyl analogue of L-365,260, a selective high affinity ligand for the CCKB/gastrin receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.94 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58699 | — | — | 1 | 9.55 |
| CHEMBL9387 | L-365260 | — | 1 | 8.07 |
| CHEMBL56944 | — | — | 1 | 7.80 |
| CHEMBL293786 | — | — | 1 | 7.52 |
| CHEMBL410035 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58699 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL9387 | L-365260 | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL56944 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL293786 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL410035 | — | IC50 | = | 169.0 | nM | 6.77 |