Assay Detail
Binding
CHEMBL656248
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Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
118
Total Activities
118
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of 1,4-benzodiazepine cholecystokinin type B antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 118 | 7.37 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137516 | — | — | 1 | 9.66 |
| CHEMBL137726 | — | — | 1 | 9.62 |
| CHEMBL313813 | — | — | 1 | 9.25 |
| CHEMBL337574 | — | — | 1 | 9.22 |
| CHEMBL342640 | — | — | 1 | 9.10 |
| CHEMBL136966 | — | — | 1 | 9.00 |
| CHEMBL38404 | — | — | 1 | 9.00 |
| CHEMBL417521 | — | — | 1 | 8.92 |
| CHEMBL2092976 | — | — | 1 | 8.85 |
| CHEMBL445095 | — | — | 1 | 8.80 |
| CHEMBL2448131 | — | — | 1 | 8.66 |
| CHEMBL136038 | — | — | 1 | 8.57 |
| CHEMBL137398 | — | — | 1 | 8.52 |
| CHEMBL542967 | — | — | 1 | 8.46 |
| CHEMBL337055 | — | — | 1 | 8.42 |
| CHEMBL2111923 | — | — | 1 | 8.42 |
| CHEMBL136608 | — | — | 1 | 8.42 |
| CHEMBL135371 | — | — | 1 | 8.36 |
| CHEMBL336765 | — | — | 1 | 8.32 |
| CHEMBL137567 | — | — | 1 | 8.31 |
| CHEMBL134340 | — | — | 1 | 8.30 |
| CHEMBL135218 | — | — | 1 | 8.25 |
| CHEMBL135538 | — | — | 1 | 8.24 |
| CHEMBL422102 | — | — | 1 | 8.23 |
| CHEMBL273919 | — | — | 1 | 8.23 |
| CHEMBL337286 | — | — | 1 | 8.22 |
| CHEMBL343767 | — | — | 1 | 8.22 |
| CHEMBL33554 | — | — | 1 | 8.19 |
| CHEMBL515268 | — | — | 1 | 8.16 |
| CHEMBL132875 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137516 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL137726 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL313813 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL337574 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL342640 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL38404 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL136966 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL417521 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2092976 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL445095 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2448131 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL136038 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL137398 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL542967 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL136608 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2111923 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL337055 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL135371 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL336765 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL137567 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL134340 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL135218 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL135538 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL273919 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL422102 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL343767 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL337286 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL33554 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL515268 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL132875 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2111924 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL9449 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL137043 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL9387 | L-365260 | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL136412 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL137066 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL136975 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL137779 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL334592 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL337065 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1907927 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2112753 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL2112751 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL169661 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL136436 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL135433 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL424076 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL135447 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL337733 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL135289 | — | IC50 | = | 26.0 | nM | 7.58 |