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Assay Detail

CHEMBL656270

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of CEM (human leukemia) cell proliferation.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Expert

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Dhar TG, Shen Z, Gu HH, Chen P, Norris D, Watterson SH, Ballentine SK, Fleener CA, Rouleau KA, Barrish JC, Townsend R, Hollenbaugh DL, Iwanowicz EJ.
Bioorg Med Chem Lett (2003) 13 : 3557 -3560
PubMed 14505670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.71 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 6.47
CHEMBL304087 MERIMEPODIB 2.0 1 6.31
CHEMBL64830 1 6.28
CHEMBL65013 1 6.00
CHEMBL333483 1 5.96
CHEMBL118115 1 5.85
CHEMBL118714 1 5.60
CHEMBL118664 1 5.55
CHEMBL120656 1 5.46
CHEMBL327031 1 5.46
CHEMBL119408 1 5.36
CHEMBL119407 1 5.31
CHEMBL333901 1 5.28
CHEMBL331535 1 5.10
CHEMBL118613 1 -
CHEMBL119208 1 -
CHEMBL118384 1 -
CHEMBL119655 1 -
CHEMBL118260 1 -
CHEMBL333662 1 -
CHEMBL118983 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL866 MYCOPHENOLIC ACID IC50 = 340.0 nM 6.47
CHEMBL304087 MERIMEPODIB IC50 = 490.0 nM 6.31
CHEMBL64830 IC50 = 520.0 nM 6.28
CHEMBL65013 IC50 = 1000.0 nM 6.00
CHEMBL333483 IC50 = 1100.0 nM 5.96
CHEMBL118115 IC50 = 1400.0 nM 5.85
CHEMBL118714 IC50 = 2500.0 nM 5.60
CHEMBL118664 IC50 = 2800.0 nM 5.55
CHEMBL120656 IC50 = 3500.0 nM 5.46
CHEMBL327031 IC50 = 3500.0 nM 5.46
CHEMBL119408 IC50 = 4400.0 nM 5.36
CHEMBL119407 IC50 = 4900.0 nM 5.31
CHEMBL333901 IC50 = 5300.0 nM 5.28
CHEMBL331535 IC50 = 8000.0 nM 5.10
CHEMBL118613 IC50 > 10000.0 nM -
CHEMBL119208 IC50 > 10000.0 nM -
CHEMBL118384 IC50 > 10000.0 nM -
CHEMBL119655 IC50 > 10000.0 nM -
CHEMBL118260 IC50 > 10000.0 nM -
CHEMBL333662 IC50 > 10000.0 nM -
CHEMBL118983 IC50 > 10000.0 nM -