Assay Detail
Functional
CHEMBL656278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of particle production in de novo infection assay of HIV infected CEM cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39092 | — | — | 1 | 6.00 |
| CHEMBL81182 | — | — | 1 | 5.70 |
| CHEMBL83746 | — | — | 1 | 5.70 |
| CHEMBL82986 | — | — | 1 | 5.40 |
| CHEMBL81714 | — | — | 1 | 5.00 |
| CHEMBL36640 | — | — | 1 | 4.92 |
| CHEMBL80008 | — | — | 1 | 4.60 |
| CHEMBL312608 | — | — | 1 | 4.52 |
| CHEMBL82633 | — | — | 1 | 4.40 |
| CHEMBL81686 | — | — | 1 | 4.35 |
| CHEMBL81284 | — | — | 1 | 4.26 |
| CHEMBL39958 | — | — | 1 | - |
| CHEMBL82029 | — | — | 1 | - |
| CHEMBL83419 | — | — | 1 | - |
| CHEMBL309885 | — | — | 1 | - |
| CHEMBL310321 | — | — | 1 | - |
| CHEMBL420026 | — | — | 1 | - |
| CHEMBL82359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39092 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL81182 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL83746 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL82986 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL81714 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36640 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL80008 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL312608 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL82633 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL81686 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL81284 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL39958 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82029 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL83419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL309885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL310321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82359 | — | IC50 | > | 100000.0 | nM | - |