Assay Detail
Functional
CHEMBL656281
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Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277985 | — | — | 1 | 7.96 |
| CHEMBL282787 | — | — | 1 | 7.64 |
| CHEMBL275237 | — | — | 1 | 7.28 |
| CHEMBL407052 | — | — | 1 | 6.24 |
| CHEMBL429036 | — | — | 1 | 5.96 |
| CHEMBL418527 | — | — | 1 | 5.95 |
| CHEMBL276704 | — | — | 1 | 5.54 |
| CHEMBL268605 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277985 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL282787 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL275237 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL407052 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL429036 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL418527 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL276704 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL268605 | — | IC50 | = | 22400.0 | nM | 4.65 |