Assay Detail
Functional
CHEMBL656300
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Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-2 in CEM cell culture.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.43 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315693 | — | — | 1 | 8.77 |
| CHEMBL423131 | — | — | 1 | 8.57 |
| CHEMBL314988 | — | — | 1 | 8.57 |
| CHEMBL315371 | — | — | 1 | 8.48 |
| CHEMBL77652 | — | — | 1 | 7.75 |
| CHEMBL313960 | — | — | 1 | 7.46 |
| CHEMBL23094 | — | — | 1 | 5.10 |
| CHEMBL290427 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315693 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL423131 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL314988 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL315371 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL77652 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL313960 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL23094 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL290427 | — | EC50 | = | 20000.0 | nM | 4.70 |