Assay Detail
Functional
CHEMBL656302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect CEM cells against cytopathicity of HIV-1 by 50%
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.39 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323261 | — | — | 1 | 7.24 |
| CHEMBL124801 | — | — | 1 | 7.05 |
| CHEMBL126572 | — | — | 1 | 6.70 |
| CHEMBL125938 | — | — | 1 | 6.26 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.19 |
| CHEMBL124586 | — | — | 1 | 6.19 |
| CHEMBL338306 | — | — | 1 | 6.12 |
| CHEMBL123953 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323261 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL124801 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL126572 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL125938 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL991 | STAVUDINE | EC50 | = | 651.0 | nM | 6.19 |
| CHEMBL124586 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL338306 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL123953 | — | EC50 | = | 4000.0 | nM | 5.40 |