Assay Detail
Functional
CHEMBL656403
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Cell growth inhibition against CEM cell from human leukemic lymphoblasts
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.00 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 32.0 | nM | 7.50 |