Assay Detail
Functional
CHEMBL656416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for anti-HIV activity in TK-deficient CEM cells by p24 production assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.91 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320833 | STAMPIDINE | — | 1 | 7.40 |
| CHEMBL107184 | — | — | 1 | 7.00 |
| CHEMBL323261 | — | — | 1 | 7.00 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320833 | STAMPIDINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL107184 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL323261 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL991 | STAVUDINE | IC50 | = | 600.0 | nM | 6.22 |