Assay Detail
Binding
CHEMBL656489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-lactamase of Citrobacter freundii 1982 (class C)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Citrobacter freundii |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.83 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128220 | — | — | 1 | 7.92 |
| CHEMBL355579 | — | — | 1 | 7.70 |
| CHEMBL607279 | — | — | 1 | 7.28 |
| CHEMBL607280 | — | — | 1 | 6.65 |
| CHEMBL128979 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128220 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL355579 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL607279 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL607280 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL128979 | — | IC50 | = | 26000.0 | nM | 4.58 |