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Assay Detail

CHEMBL656586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition against CH-1 wild-type ovarian cell lines
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CH1
Confidence 1 — Organism
Curated By Expert

Target

CH1 (CHEMBL614455)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.
Pors K, Paniwnyk Z, Ruparelia KC, Teesdale-Spittle PH, Hartley JA, Kelland LR, Patterson LH.
J Med Chem (2004) 47 : 1856 -1859
PubMed 15027879 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.70 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300531 1 8.15
CHEMBL53843 1 8.10
CHEMBL55820 1 7.75
CHEMBL55845 1 7.62
CHEMBL57109 1 7.60
CHEMBL293516 1 7.52
CHEMBL53164 1 7.52
CHEMBL417917 1 7.27
CHEMBL55064 1 7.11
CHEMBL11359 CISPLATIN 4.0 1 7.00
CHEMBL53117 1 6.96
CHEMBL51686 1 6.73
CHEMBL55955 1 6.52
CHEMBL52667 1 6.24
CHEMBL52364 1 6.17
CHEMBL55016 1 5.84
CHEMBL54868 1 5.66
CHEMBL51751 1 5.60
CHEMBL51757 1 5.58
CHEMBL296381 1 5.54
CHEMBL515 CHLORAMBUCIL 4.0 1 5.48
CHEMBL418094 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300531 IC50 = 7.0 nM 8.15
CHEMBL53843 IC50 = 8.0 nM 8.10
CHEMBL55820 IC50 = 18.0 nM 7.75
CHEMBL55845 IC50 = 24.0 nM 7.62
CHEMBL57109 IC50 = 25.0 nM 7.60
CHEMBL293516 IC50 = 30.0 nM 7.52
CHEMBL53164 IC50 = 30.0 nM 7.52
CHEMBL417917 IC50 = 54.0 nM 7.27
CHEMBL55064 IC50 = 78.0 nM 7.11
CHEMBL11359 CISPLATIN IC50 = 100.0 nM 7.00
CHEMBL53117 IC50 = 110.0 nM 6.96
CHEMBL51686 IC50 = 185.0 nM 6.73
CHEMBL55955 IC50 = 300.0 nM 6.52
CHEMBL52667 IC50 = 580.0 nM 6.24
CHEMBL52364 IC50 = 680.0 nM 6.17
CHEMBL55016 IC50 = 1440.0 nM 5.84
CHEMBL54868 IC50 = 2200.0 nM 5.66
CHEMBL51751 IC50 = 2500.0 nM 5.60
CHEMBL51757 IC50 = 2600.0 nM 5.58
CHEMBL296381 IC50 = 2900.0 nM 5.54
CHEMBL515 CHLORAMBUCIL IC50 = 3300.0 nM 5.48
CHEMBL418094 IC50 = 3900.0 nM 5.41