Assay Detail
Binding
CHEMBL656659
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Inhibition of cathepsin B with Cbz-L-lysine-p-nitrophenyl ester as substrate
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.02 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373045 | — | — | 1 | 8.40 |
| CHEMBL2373041 | — | — | 1 | 7.41 |
| CHEMBL2373042 | — | — | 1 | 7.00 |
| CHEMBL2373051 | — | — | 1 | 6.89 |
| CHEMBL2373046 | — | — | 1 | 6.82 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 6.51 |
| CHEMBL2373053 | — | — | 1 | 5.96 |
| CHEMBL2373060 | — | — | 1 | 5.82 |
| CHEMBL2373064 | — | — | 1 | 5.80 |
| CHEMBL2373049 | — | — | 1 | 5.70 |
| CHEMBL2373052 | — | — | 1 | 4.75 |
| CHEMBL2373044 | — | — | 1 | 4.66 |
| CHEMBL2373050 | — | — | 1 | 4.55 |
| CHEMBL2373062 | — | — | 1 | 4.00 |
| CHEMBL2373061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373045 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2373041 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2373042 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2373051 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2373046 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2373053 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2373060 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2373064 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2373049 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2373052 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2373044 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2373050 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2373062 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2373061 | — | IC50 | = | 130000.0 | nM | - |