Assay Detail
Binding
CHEMBL656676
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Inhibitory activity against recombinant human cathepsin K
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.10 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | — | 1 | 9.96 |
| CHEMBL315651 | — | — | 1 | 7.82 |
| CHEMBL96284 | — | — | 1 | 7.82 |
| CHEMBL330718 | — | — | 1 | 7.80 |
| CHEMBL313847 | — | — | 1 | 7.64 |
| CHEMBL92567 | — | — | 1 | 7.58 |
| CHEMBL94891 | — | — | 1 | 7.58 |
| CHEMBL92972 | — | — | 1 | 7.54 |
| CHEMBL92025 | — | — | 1 | 7.52 |
| CHEMBL96823 | — | — | 1 | 7.51 |
| CHEMBL447231 | — | — | 1 | 7.44 |
| CHEMBL94616 | — | — | 1 | 7.42 |
| CHEMBL96669 | — | — | 1 | 7.42 |
| CHEMBL96508 | — | — | 1 | 7.40 |
| CHEMBL92971 | — | — | 1 | 7.39 |
| CHEMBL96341 | — | — | 1 | 7.39 |
| CHEMBL92465 | — | — | 1 | 7.30 |
| CHEMBL91968 | — | — | 1 | 7.29 |
| CHEMBL96875 | — | — | 1 | 7.29 |
| CHEMBL93420 | — | — | 1 | 7.24 |
| CHEMBL91874 | — | — | 1 | 7.11 |
| CHEMBL96482 | — | — | 1 | 7.10 |
| CHEMBL93911 | — | — | 1 | 7.08 |
| CHEMBL94820 | — | — | 1 | 7.06 |
| CHEMBL92993 | — | — | 1 | 7.01 |
| CHEMBL540696 | — | — | 1 | 6.96 |
| CHEMBL94327 | — | — | 1 | 6.96 |
| CHEMBL319662 | — | — | 1 | 6.89 |
| CHEMBL94383 | — | — | 1 | 6.82 |
| CHEMBL92826 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL315651 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL96284 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL330718 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL313847 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL92567 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL94891 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL92972 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL92025 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL96823 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL447231 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL94616 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL96669 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL96508 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL96341 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL92971 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL92465 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL91968 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL96875 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL93420 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL91874 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL96482 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL93911 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL94820 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL92993 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL540696 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL94327 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL319662 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL94383 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL92826 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL94727 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL330046 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL94150 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL318817 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL94695 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL94253 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL92991 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL94805 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL94782 | — | IC50 | = | 52000.0 | nM | 4.28 |