Assay Detail
Binding
CHEMBL656680
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Inhibitory activity against human cathepsin K
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of small molecule ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.70 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | — | 1 | 9.96 |
| CHEMBL354473 | — | — | 1 | 9.15 |
| CHEMBL163286 | — | — | 1 | 9.10 |
| CHEMBL349045 | — | — | 1 | 8.96 |
| CHEMBL355138 | — | — | 1 | 8.20 |
| CHEMBL164373 | — | — | 1 | 7.70 |
| CHEMBL162041 | — | — | 1 | 7.50 |
| CHEMBL163185 | — | — | 1 | 7.47 |
| CHEMBL96875 | — | — | 1 | 7.29 |
| CHEMBL163757 | — | — | 1 | 7.16 |
| CHEMBL351877 | — | — | 1 | 7.12 |
| CHEMBL266851 | — | — | 1 | 6.04 |
| CHEMBL162812 | — | — | 1 | 5.92 |
| CHEMBL163240 | — | — | 1 | 5.85 |
| CHEMBL162793 | — | — | 1 | 5.54 |
| CHEMBL439649 | — | — | 1 | 5.47 |
| CHEMBL163555 | — | — | 1 | 5.38 |
| CHEMBL159411 | — | — | 1 | 5.30 |
| CHEMBL159569 | — | — | 1 | 5.23 |
| CHEMBL164535 | — | — | 1 | 5.20 |
| CHEMBL159452 | — | — | 1 | 5.04 |
| CHEMBL346748 | — | — | 1 | 4.75 |
| CHEMBL159905 | — | — | 1 | 4.68 |
| CHEMBL159869 | — | — | 1 | - |
| CHEMBL84691 | — | — | 1 | - |
| CHEMBL165345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL354473 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL163286 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL349045 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL355138 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL164373 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL162041 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL163185 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL96875 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL163757 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL351877 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL266851 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL162812 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL163240 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL162793 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL439649 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL163555 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL159411 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL159569 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL164535 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL159452 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL346748 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL159905 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL159869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL84691 | — | IC50 | = | 2.5 | nM | - |
| CHEMBL165345 | — | IC50 | > | 100000.0 | nM | - |