Assay Detail
Binding
CHEMBL656685
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Inhibitory concentration against recombinant human cathepsin K
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.86 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86088 | — | — | 1 | 6.00 |
| CHEMBL84691 | — | — | 1 | 5.60 |
| CHEMBL85977 | — | — | 1 | 4.89 |
| CHEMBL421544 | — | — | 1 | 4.85 |
| CHEMBL87961 | — | — | 1 | 4.85 |
| CHEMBL418935 | — | — | 1 | 4.75 |
| CHEMBL445898 | — | — | 1 | 4.72 |
| CHEMBL83563 | — | — | 1 | 4.64 |
| CHEMBL87332 | — | — | 1 | 4.52 |
| CHEMBL446669 | — | — | 1 | 4.36 |
| CHEMBL87946 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86088 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL84691 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL85977 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL421544 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL87961 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL418935 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL445898 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL83563 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL87332 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL446669 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL87946 | — | IC50 | = | 59000.0 | nM | 4.23 |