Assay Detail
Functional
CHEMBL656719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of sensitivity of multidrug resistant chinese hamster ovary cell line CHRC/5 expressed as concentration that restores 50% of cytotoxic activity of 5 ug/mL toward doxorubicin
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHRC5 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and activity against multidrug resistance in Chinese hamster ovary cells of new acridone-4-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 62 | 6.83 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78571 | — | — | 1 | 7.75 |
| CHEMBL80012 | — | — | 1 | 7.68 |
| CHEMBL396298 | ELACRIDAR | 2.0 | 1 | 7.68 |
| CHEMBL77905 | — | — | 1 | 7.68 |
| CHEMBL309650 | — | — | 1 | 7.68 |
| CHEMBL81789 | — | — | 1 | 7.66 |
| CHEMBL309747 | — | — | 1 | 7.57 |
| CHEMBL81815 | — | — | 1 | 7.52 |
| CHEMBL81344 | — | — | 1 | 7.52 |
| CHEMBL84388 | — | — | 1 | 7.48 |
| CHEMBL81634 | — | — | 1 | 7.44 |
| CHEMBL81515 | — | — | 1 | 7.43 |
| CHEMBL81918 | — | — | 1 | 7.40 |
| CHEMBL82036 | — | — | 1 | 7.37 |
| CHEMBL78309 | — | — | 1 | 7.35 |
| CHEMBL312112 | — | — | 1 | 7.35 |
| CHEMBL77516 | — | — | 1 | 7.32 |
| CHEMBL3706600 | — | — | 1 | 7.30 |
| CHEMBL275447 | — | — | 1 | 7.22 |
| CHEMBL78077 | — | — | 1 | 7.20 |
| CHEMBL82082 | — | — | 1 | 7.10 |
| CHEMBL310169 | — | — | 1 | 7.06 |
| CHEMBL546783 | — | — | 1 | 7.05 |
| CHEMBL81323 | — | — | 1 | 7.05 |
| CHEMBL82025 | — | — | 1 | 7.05 |
| CHEMBL312428 | — | — | 1 | 7.05 |
| CHEMBL82721 | — | — | 1 | 7.03 |
| CHEMBL3706587 | — | — | 1 | 6.96 |
| CHEMBL84460 | — | — | 1 | 6.92 |
| CHEMBL83803 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78571 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL80012 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL396298 | ELACRIDAR | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL77905 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL309650 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL81789 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL309747 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL81815 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL81344 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL84388 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL81634 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL81515 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL81918 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL82036 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL312112 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL78309 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL77516 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3706600 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL275447 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL78077 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL82082 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL310169 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL312428 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL82025 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL546783 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL81323 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL82721 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3706587 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL84460 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL83803 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL78588 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL77560 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL78725 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3706595 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL309731 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL309973 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL82875 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL309734 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3706589 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3706597 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL311200 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL310640 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL310318 | — | EC50 | = | 305.0 | nM | 6.52 |
| CHEMBL78910 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL532012 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL431789 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3706588 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL77500 | — | EC50 | = | 465.0 | nM | 6.33 |
| CHEMBL3706598 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3706599 | — | EC50 | = | 525.0 | nM | 6.28 |