Assay Detail
Functional
CHEMBL656735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of HIV-1 replication in human T-lymphocytic cells (CEM).
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.62 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL42698 | — | — | 1 | 7.60 |
| CHEMBL416624 | — | — | 1 | 7.52 |
| CHEMBL41053 | — | — | 3 | 7.37 |
| CHEMBL289937 | — | — | 1 | 7.33 |
| CHEMBL40302 | — | — | 1 | 7.33 |
| CHEMBL41402 | — | — | 1 | 7.30 |
| CHEMBL40598 | — | — | 1 | 7.19 |
| CHEMBL289329 | — | — | 1 | 7.19 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.75 |
| CHEMBL288769 | — | — | 1 | 5.96 |
| CHEMBL290935 | — | — | 1 | 5.46 |
| CHEMBL23094 | — | — | 1 | 5.37 |
| CHEMBL42533 | — | — | 1 | 5.37 |
| CHEMBL295820 | — | — | 1 | 5.28 |
| CHEMBL290427 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42698 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL416624 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL41053 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL289937 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL40302 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL41402 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL289329 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL40598 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL41053 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL991 | STAVUDINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL41053 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL288769 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL290935 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL23094 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL42533 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL295820 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL290427 | — | EC50 | = | 30000.0 | nM | 4.52 |