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Assay Detail

CHEMBL656737

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of HIV-2 replication in human T-lymphocytic cells (CEM).
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 2 (CHEMBL380)
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
Meier C, Knispel T, De Clercq E, Balzarini J.
J Med Chem (1999) 42 : 1604 -1614
PubMed 10229629 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.50 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129 ZIDOVUDINE 4.0 1 8.22
CHEMBL42698 1 7.60
CHEMBL40302 1 7.52
CHEMBL41053 3 7.30
CHEMBL41402 1 7.26
CHEMBL416624 1 6.89
CHEMBL289937 1 6.80
CHEMBL40598 1 6.72
CHEMBL991 STAVUDINE 4.0 1 6.58
CHEMBL289329 1 6.46
CHEMBL288769 1 6.16
CHEMBL23094 1 5.35
CHEMBL295820 1 5.30
CHEMBL290935 1 4.40
CHEMBL290427 1 4.30
CHEMBL42533 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129 ZIDOVUDINE EC50 = 6.0 nM 8.22
CHEMBL42698 EC50 = 25.0 nM 7.60
CHEMBL40302 EC50 = 30.0 nM 7.52
CHEMBL41053 EC50 = 50.0 nM 7.30
CHEMBL41402 EC50 = 55.0 nM 7.26
CHEMBL41053 EC50 = 65.0 nM 7.19
CHEMBL416624 EC50 = 130.0 nM 6.89
CHEMBL289937 EC50 = 160.0 nM 6.80
CHEMBL40598 EC50 = 190.0 nM 6.72
CHEMBL991 STAVUDINE EC50 = 260.0 nM 6.58
CHEMBL41053 EC50 = 330.0 nM 6.48
CHEMBL289329 EC50 = 350.0 nM 6.46
CHEMBL288769 EC50 = 700.0 nM 6.16
CHEMBL23094 EC50 = 4500.0 nM 5.35
CHEMBL295820 EC50 = 5000.0 nM 5.30
CHEMBL290935 EC50 = 40000.0 nM 4.40
CHEMBL290427 EC50 = 50000.0 nM 4.30
CHEMBL42533 EC50 > 50000.0 nM -