Assay Detail
Functional
CHEMBL656738
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Antiviral activity evaluated as the ability to inhibit the replication of HIV-2 in human T-lymphocytic cells (CEM)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.14 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.58 |
| CHEMBL295071 | — | — | 1 | 5.73 |
| CHEMBL2111583 | — | — | 1 | 5.48 |
| CHEMBL297105 | — | — | 1 | 5.45 |
| CHEMBL23094 | — | — | 1 | 5.34 |
| CHEMBL44302 | — | — | 1 | 5.25 |
| CHEMBL2112391 | — | — | 1 | 4.90 |
| CHEMBL40874 | — | — | 1 | 4.89 |
| CHEMBL42392 | — | — | 1 | 4.60 |
| CHEMBL432291 | — | — | 1 | 4.52 |
| CHEMBL42467 | — | — | 1 | 4.50 |
| CHEMBL501916 | LODENOSINE | 2.0 | 1 | 4.40 |
| CHEMBL2114462 | — | — | 1 | - |
| CHEMBL42429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL295071 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2111583 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL297105 | — | EC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL23094 | — | EC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL44302 | — | EC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL2112391 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL40874 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL42392 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL432291 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL42467 | — | EC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL501916 | LODENOSINE | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2114462 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL42429 | — | EC50 | > | 250000.0 | nM | - |