Assay Detail
Functional
CHEMBL656739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.10 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418833 | — | — | 1 | 7.70 |
| CHEMBL105916 | — | — | 1 | 7.60 |
| CHEMBL105976 | — | — | 1 | 7.60 |
| CHEMBL58711 | TIVIRAPINE | 2.0 | 1 | 7.52 |
| CHEMBL418812 | — | — | 1 | 7.50 |
| CHEMBL110091 | — | — | 1 | 7.21 |
| CHEMBL107535 | — | — | 1 | 6.91 |
| CHEMBL107099 | — | — | 1 | 6.70 |
| CHEMBL320557 | — | — | 1 | 6.50 |
| CHEMBL108221 | — | — | 1 | 6.42 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418833 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL105916 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL105976 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL58711 | TIVIRAPINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL418812 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL110091 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL107535 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL107099 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL320557 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL108221 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 400.0 | nM | 6.40 |