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Assay Detail

CHEMBL656767

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Intermediate

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
Yu KL, Bronson JJ, Yang H, Patick A, Alam M, Brankovan V, Datema R, Hitchcock MJ, Martin JC.
J Med Chem (1992) 35 : 2958 -2969
PubMed 1323678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 5.54 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL223737 GS-438 -1.0 1 6.70
CHEMBL92761 1 6.00
CHEMBL99758 1 5.58
CHEMBL19976 1 5.30
CHEMBL91794 1 4.92
CHEMBL484 ADEFOVIR 3.0 1 4.75
CHEMBL264868 1 -
CHEMBL92289 1 -
CHEMBL98367 1 -
CHEMBL419692 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL223737 GS-438 EC50 = 200.0 nM 6.70
CHEMBL92761 EC50 = 1000.0 nM 6.00
CHEMBL99758 EC50 = 2600.0 nM 5.58
CHEMBL19976 EC50 = 5000.0 nM 5.30
CHEMBL91794 EC50 = 12000.0 nM 4.92
CHEMBL484 ADEFOVIR EC50 = 18000.0 nM 4.75
CHEMBL264868 EC50 > 100000.0 nM -
CHEMBL92289 EC50 > 500000.0 nM -
CHEMBL98367 EC50 > 100000.0 nM -
CHEMBL419692 EC50 = 500000.0 nM -