Assay Detail
Functional
CHEMBL656787
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In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bradykinin receptor antagonists containing N-substituted amino acids: in vitro and in vivo B(2) and B(1) receptor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.77 | 6.41 |
| -Log IC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3038105 | — | — | 1 | 6.41 |
| CHEMBL3038104 | — | — | 1 | 5.79 |
| CHEMBL3038096 | — | — | 1 | 5.52 |
| CHEMBL3038103 | — | — | 1 | 5.34 |
| CHEMBL3038099 | — | — | 1 | - |
| CHEMBL2028982 | — | — | 1 | - |
| CHEMBL3038095 | — | — | 1 | - |
| CHEMBL3038102 | — | — | 1 | - |
| CHEMBL3038098 | — | — | 1 | - |
| CHEMBL3038097 | — | — | 1 | - |
| CHEMBL3038094 | — | — | 1 | - |
| CHEMBL2028850 | ICATIBANT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3038105 | — | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL3038104 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL3038096 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL3038103 | — | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL3038099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3038095 | — | -Log IC50 | - | — | - | |
| CHEMBL3038102 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3038098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3038097 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3038094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028850 | ICATIBANT | -Log IC50 | - | — | - |