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Compound Detail

CHEMBL3038103

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NC(N)=NCCC[C@H](NC(=O)CN(C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1CCCC1)C1CCCCC1)C(=O)O

Basic Information

ChEMBL ID CHEMBL3038103
Phase Preclinical
Structure Type BOTH
InChI Key UMNBFHMYNMLTCX-YRJLALSUSA-N
4
Targets
4
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

1258.5
MW (Da)

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C55H91N19O13S
MW 1258.52

Activity Summary

Ki 2 meas. best 7.64
IC50 1 meas. best 5.34
Kd 1 meas. best 5.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
B2 bradykinin receptor
CHEMBL3157
Ki 7.64 7.64 22.9 1
Unchecked
CHEMBL612545
Ki 7.56 7.56 27.5 1
B2 bradykinin receptor
CHEMBL2501
Kd 5.85 5.85 1412.5 1
B1 bradykinin receptor
CHEMBL4308
IC50 5.34 5.34 4570.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8691478 10.1021/jm950716i B2 bradykinin receptor 2
8691478 10.1021/jm950716i Rattus norvegicus 1
8691478 10.1021/jm950716i B1 bradykinin receptor 1
8691478 10.1021/jm950716i Unchecked 1

Data from ChEMBL 36 via Core Engine