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Assay Detail

CHEMBL657653

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards bradykinin receptor using [3H]BK as radioligand in guinea pig ileum
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Ileum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bradykinin receptor antagonists containing N-substituted amino acids: in vitro and in vivo B(2) and B(1) receptor antagonist activity.
Goodfellow VS, Marathe MV, Kuhlman KG, Fitzpatrick TD, Cuadrado D, Hanson W, Zuzack JS, Ross SE, Wieczorek M, Burkard M, Whalley ET.
J Med Chem (1996) 39 : 1472 -1484
PubMed 8691478 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 8.95 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3038106 1 10.22
CHEMBL2028850 ICATIBANT 4.0 1 10.18
CHEMBL3038099 1 10.11
CHEMBL3038098 1 10.09
CHEMBL3038094 1 9.96
CHEMBL3038095 1 9.92
CHEMBL406291 BRADYKININ 2.0 1 9.58
CHEMBL3038096 1 8.98
CHEMBL3038100 1 8.85
CHEMBL3038102 1 8.32
CHEMBL3038101 1 8.12
CHEMBL3038103 1 7.56
CHEMBL2372276 1 7.45
CHEMBL3038105 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3038106 Ki = 0.06026 nM 10.22
CHEMBL2028850 ICATIBANT Ki = 0.06607 nM 10.18
CHEMBL3038099 Ki = 0.07762 nM 10.11
CHEMBL3038098 Ki = 0.08128 nM 10.09
CHEMBL3038094 Ki = 0.1096 nM 9.96
CHEMBL3038095 Ki = 0.1202 nM 9.92
CHEMBL406291 BRADYKININ Ki = 0.263 nM 9.58
CHEMBL3038096 Ki = 1.047 nM 8.98
CHEMBL3038100 Ki = 1.413 nM 8.85
CHEMBL3038102 Ki = 4.786 nM 8.32
CHEMBL3038101 Ki = 7.586 nM 8.12
CHEMBL3038103 Ki = 27.54 nM 7.56
CHEMBL2372276 Ki = 35.48 nM 7.45
CHEMBL3038105 Ki = 1096.48 nM 5.96