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Assay Detail

CHEMBL857781

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Binding
Binding affinity towards Bradykinin receptor B2 in human S34 clone cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type S34
Confidence 8 — Homologous single protein target
Curated By Expert

Target

B2 bradykinin receptor (CHEMBL3157)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bradykinin receptor antagonists containing N-substituted amino acids: in vitro and in vivo B(2) and B(1) receptor antagonist activity.
Goodfellow VS, Marathe MV, Kuhlman KG, Fitzpatrick TD, Cuadrado D, Hanson W, Zuzack JS, Ross SE, Wieczorek M, Burkard M, Whalley ET.
J Med Chem (1996) 39 : 1472 -1484
PubMed 8691478 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.57 9.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3038098 1 9.78
CHEMBL2028850 ICATIBANT 4.0 1 9.74
CHEMBL3038106 1 9.69
CHEMBL3038094 1 9.41
CHEMBL3038095 1 9.40
CHEMBL406291 BRADYKININ 2.0 1 9.17
CHEMBL3038096 1 8.57
CHEMBL3038102 1 8.05
CHEMBL3038100 1 7.92
CHEMBL2372276 1 7.90
CHEMBL3038101 1 7.84
CHEMBL3038103 1 7.64
CHEMBL3038105 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3038098 Ki = 0.166 nM 9.78
CHEMBL2028850 ICATIBANT Ki = 0.182 nM 9.74
CHEMBL3038106 Ki = 0.2042 nM 9.69
CHEMBL3038094 Ki = 0.389 nM 9.41
CHEMBL3038095 Ki = 0.3981 nM 9.40
CHEMBL406291 BRADYKININ Ki = 0.6761 nM 9.17
CHEMBL3038096 Ki = 2.692 nM 8.57
CHEMBL3038102 Ki = 8.913 nM 8.05
CHEMBL3038100 Ki = 12.02 nM 7.92
CHEMBL2372276 Ki = 12.59 nM 7.90
CHEMBL3038101 Ki = 14.45 nM 7.84
CHEMBL3038103 Ki = 22.91 nM 7.64
CHEMBL3038105 Ki = 575.44 nM 6.24