Assay Detail
Functional
CHEMBL656798
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In vitro cytotoxic activity against CCRF-CEM human lymphoblastoid cells in culture.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Palladium-catalysed synthesis of some biologically active 5, 6-disubstituted uracils
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.58 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83380 | — | — | 1 | 5.85 |
| CHEMBL83737 | — | — | 1 | 5.75 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.70 |
| CHEMBL83554 | — | — | 1 | 5.66 |
| CHEMBL83204 | — | — | 1 | 5.58 |
| CHEMBL317488 | — | — | 1 | 5.58 |
| CHEMBL313456 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83380 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL83737 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL83554 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL83204 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL317488 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL313456 | — | IC50 | = | 12200.0 | nM | 4.91 |