Assay Detail
Functional
CHEMBL656826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of multidrug resistance associated protein type 1 (MRP1) assayed by an accumulation assay in COR.L23/R cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.38 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356478 | — | — | 1 | 6.40 |
| CHEMBL156947 | — | — | 1 | 6.30 |
| CHEMBL435437 | — | — | 1 | 6.05 |
| CHEMBL152590 | — | — | 1 | 6.00 |
| CHEMBL154003 | — | — | 1 | 6.00 |
| CHEMBL421980 | — | — | 1 | 5.98 |
| CHEMBL423413 | — | — | 1 | 5.88 |
| CHEMBL157318 | — | — | 1 | 5.82 |
| CHEMBL346486 | — | — | 1 | 5.81 |
| CHEMBL264490 | — | — | 1 | 5.70 |
| CHEMBL357064 | — | — | 1 | 5.55 |
| CHEMBL152157 | — | — | 1 | 5.54 |
| CHEMBL347672 | — | — | 1 | 5.50 |
| CHEMBL154004 | — | — | 1 | 5.48 |
| CHEMBL156894 | — | — | 1 | 5.42 |
| CHEMBL433715 | — | — | 1 | 5.35 |
| CHEMBL350775 | BIRICODAR | 2.0 | 1 | 5.29 |
| CHEMBL154596 | — | — | 1 | 5.20 |
| CHEMBL356477 | — | — | 1 | 5.14 |
| CHEMBL152447 | — | — | 1 | 5.12 |
| CHEMBL348567 | — | — | 1 | 5.00 |
| CHEMBL152651 | — | — | 1 | 4.82 |
| CHEMBL154430 | — | — | 1 | 4.73 |
| CHEMBL154490 | — | — | 1 | 4.44 |
| CHEMBL157162 | — | — | 1 | 4.43 |
| CHEMBL357996 | — | — | 1 | 4.41 |
| CHEMBL347213 | — | — | 1 | 4.02 |
| CHEMBL153452 | — | — | 1 | - |
| CHEMBL345316 | — | — | 1 | - |
| CHEMBL152046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356478 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL156947 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL435437 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL152590 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL154003 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL421980 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL423413 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL157318 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL346486 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL264490 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL357064 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL152157 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL347672 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL154004 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL156894 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL433715 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL350775 | BIRICODAR | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL154596 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL356477 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL152447 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL348567 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL152651 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL154430 | — | IC50 | = | 18570.0 | nM | 4.73 |
| CHEMBL154490 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL157162 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL357996 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL347213 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL153452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL152046 | — | IC50 | > | 100000.0 | nM | - |