Assay Detail
Functional
CHEMBL656832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of COS cells in monkey.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Cell Type | COS-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.84 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41934 | — | — | 1 | 6.22 |
| CHEMBL336219 | — | — | 1 | 6.10 |
| CHEMBL289404 | — | — | 1 | 6.00 |
| CHEMBL337204 | — | — | 1 | 6.00 |
| CHEMBL63804 | — | — | 1 | 6.00 |
| CHEMBL334635 | — | — | 1 | 6.00 |
| CHEMBL428979 | — | — | 1 | 6.00 |
| CHEMBL342686 | — | — | 1 | 5.51 |
| CHEMBL337193 | — | — | 1 | 5.47 |
| CHEMBL336824 | — | — | 1 | 5.46 |
| CHEMBL335685 | — | — | 1 | 5.43 |
| CHEMBL344691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41934 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL336219 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL289404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL337204 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL63804 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL334635 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL428979 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL342686 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL337193 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL336824 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL335685 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL344691 | — | IC50 | > | 10000.0 | nM | - |