Assay Detail
Functional
CHEMBL656833
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Inhibitory activity was measured against COS cell
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Cell Type | COS-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.25 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39153 | — | — | 1 | 6.40 |
| CHEMBL416231 | — | — | 1 | 6.22 |
| CHEMBL41934 | — | — | 1 | 6.22 |
| CHEMBL41473 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39153 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL416231 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL41934 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL41473 | — | IC50 | = | 700.0 | nM | 6.16 |